To set a standart auto_prepend_file for php on a dedicated root server is not a bit thing but on a virtual webhosting or managed server it could be a big issue. Because you dont have systemwide global access to httpd.conf and php.ini files.
My small solutions for Hostrurope managed virtual hosting packets:
Add this line to your .htaccess file
php_value auto_prepend_file /is/htdocs/wp1193698874_ABCDEFGH/www/auto_prepend.php
And be sure that your auto_prepend.php really exists and its path is correct.